| 摘要 |
ᠵᠤᠷᠢᠯᠭᠠ᠄ ᠳᠦᠷᠪᠡᠨ ᠾᠯᠤᠷᠲᠤ ᠨᠡᠭᠦᠷᠡᠰᠦᠳᠦ᠋ᠷᠦᠭᠴᠢ ᠪᠡ ᠭᠠᠬᠠᠢᠦ ᠶᠢᠨ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠠᠴᠠ ᠪᠤᠯᠤᠭᠰᠠᠨ ᠲᠤᠮᠤ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠶᠢᠨ ᠡᠯᠢᠭᠡᠨ ᠪᠦᠳᠦᠭᠦᠷᠡᠯ ᠡᠪᠡᠳᠴᠢᠨ ᠦ ᠵᠠᠭᠪᠤᠷ ᠢ ᠵᠤᠬᠢᠶᠠᠵᠤ᠂ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠤᠨ ᠰᠤᠳᠤᠯᠤᠭᠰᠠᠨ ᠪᠠᠢ᠌ᠨᠠ᠃ ᠠᠷᠭᠠ᠄ Wistar ᠲᠤᠮᠤ ᠡᠷᠡ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠶᠢ ᠪᠡᠶᠡ ᠶᠢᠨ ᠬᠦᠨᠳᠦ ᠪᠡᠷ ᠨᠢ ᠲᠠᠰᠢᠷᠠᠮ ᠰᠠᠴᠠᠭᠤ ᠪᠠᠷ ᠬᠤᠭᠤᠰᠤᠨ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ᠂ ᠳᠦᠷᠪᠡᠨ ᠾᠯᠤᠷᠲᠤ ᠨᠡᠭᠦᠷᠡᠰᠦᠳᠦ᠋ᠷᠦᠭᠴᠢ ᠶᠢᠨ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ᠂ ᠭᠠᠬᠠᠢ ᠶᠢᠨ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠤᠨ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠵᠡᠷᠭᠡ 3 ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠬᠤᠪᠢᠶᠠᠵᠤ᠂ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠪᠦᠷᠢ ᠳᠦ 12 ᠬᠤᠯᠤᠭᠠᠨᠠ ᠬᠤᠪᠢᠶᠠᠪᠠ᠃ ᠳᠦᠷᠪᠡᠨ ᠾᠯᠤᠷᠲᠤ ᠨᠡᠭᠦᠷᠡᠰᠦᠳᠦ᠋ᠷᠦᠭᠴᠢ ᠶᠢᠨ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠪᠦᠷᠢ ᠶᠢᠨ ᠬᠡᠪᠡᠯᠢ ᠳᠦ ᠨᠢ 30%᠋᠋ ᠶᠢᠨ ᠳᠦᠷᠪᠡᠨ ᠾᠯᠤᠷᠲᠤ ᠨᠡᠭᠦᠷᠡᠰᠦᠳᠦ᠋ᠷᠦᠭᠴᠢᠲᠦ ᠬᠤᠸᠠᠱᠧᠩ ᠤᠨ ᠲᠤᠰᠤᠨ ᠠᠭᠤᠰᠤᠮᠠᠯ ᠢ 2.0ml/kg᠋ ᠪᠠᠷ ᠭᠠᠷᠠᠭ ᠲᠤ 2 ᠤᠳᠠᠭᠠ ᠪᠠᠷ ᠦᠷᠭᠦᠯᠵᠢᠯᠡᠨ 7 ᠭᠠᠷᠠᠭ ᠲᠠᠷᠢᠵᠤ᠂ ᠡᠯᠢᠭᠡᠨ ᠪᠦᠳᠦᠭᠦᠷᠡᠯ ᠡᠪᠡᠳᠴᠢᠨ ᠦ ᠵᠠᠭᠪᠤᠷ ᠢ ᠵᠤᠬᠢᠶᠠᠵᠤ᠂ ᠭᠠᠬᠠᠢ ᠶᠢᠨ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠤᠨ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠪᠦᠷᠢ ᠶᠢᠨ ᠬᠡᠡᠯᠢ ᠳᠦ ᠨᠢ ᠭᠠᠬᠠᠢ ᠶᠢᠨ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠢ 0.5ml ᠲᠠᠷᠢᠵᠤ᠂ ᠡᠯᠢᠭᠡᠨ ᠪᠦᠳᠦᠭᠦᠷᠡᠯ ᠡᠪᠡᠳᠴᠢᠨ ᠦ ᠵᠠᠭᠪᠤᠷ ᠢ ᠵᠤᠬᠢᠶᠠᠪᠠ᠃ ᠲᠤᠮᠤ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠪᠠᠷ 7 ᠭᠠᠷᠠᠭ ᠵᠠᠭᠪᠤᠷ ᠵᠤᠬᠢᠶᠠᠭᠰᠠᠨ ᠤ ᠳᠠᠷᠠᠭᠠ ᠮᠢᠨᠴᠦᠭᠦᠷᠡᠭᠦᠯᠦᠨ ᠠᠯᠠᠵᠤ᠂ ᠬᠡᠪᠡᠯᠢ ᠶᠢᠨ ᠬᠦᠨᠳᠡᠢ ᠶᠢᠨ ᠯᠤᠭᠰᠢᠭᠤᠨ ᠰᠤᠳᠠᠯ ᠠᠴᠠ ᠨᠢ 8ml ᠴᠢᠰᠦ ᠠᠪᠴᠤ᠂ 3000r/min ᠬᠤᠷᠳᠤᠴᠠ ᠪᠠᠷ 10min ᠵᠢᠭᠤᠳᠠᠭᠤᠯᠵᠤ᠂ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠢ ᠨᠢ ᠠᠪᠴᠤ᠂ AST, ALT, ALP, TP, ALB, TBIL᠋ ᠶᠢ ᠪᠠᠢ᠌ᠴᠠᠭᠠᠵᠤ᠂ ᠡᠯᠢᠭᠡᠨ ᠦ ᠵᠡᠭᠦᠨ ᠨᠠᠪᠴᠢᠨ ᠠᠴᠠ ᠨᠢ 0.3g ᠠᠪᠴᠤ᠂ 10%᠋ ᠶᠢᠨ ᠡᠯᠢᠭᠡᠨ ᠨᠡᠭᠡᠳᠡᠰᠦᠨ ᠦ ᠡᠭᠡᠳᠡᠩ ᠬᠢᠵᠦ᠂ ᠡᠯᠢᠭᠡᠨ ᠨᠡᠭᠡᠳᠡᠰᠦᠨ ᠦ HyP᠋ ᠶᠢ ᠪᠠᠢ᠌ᠴᠠᠭᠠᠪᠠ᠃ ᠦᠷᠡ ᠳ᠋ᠦᠩ᠄ ᠳᠦᠷᠪᠡᠨ ᠾᠯᠤᠷᠲᠤ ᠨᠡᠭᠦᠷᠡᠰᠦᠳᠦ᠋ᠷᠦᠭᠴᠢ ᠡᠴᠡ ᠪᠤᠯᠤᠭᠰᠠᠨ ᠲᠤᠮᠤ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠶᠢᠨ ᠡᠯᠢᠭᠡᠨ ᠪᠦᠳᠦᠭᠦᠡᠯ ᠡᠪᠡᠳᠴᠢᠨ ᠦ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ᠪᠡᠶᠡ ᠶᠢᠨ ᠬᠦᠨᠳᠦ ᠨᠢ ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠪᠠᠭᠤᠷᠠᠵᠤ᠂ ᠡᠯᠢᠭᠡᠨ ᠦ ᠵᠢᠭᠠᠯᠲᠠ ᠲᠤᠭᠠ ᠨᠢ ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠳᠡᠭᠡᠭ᠍ᠰᠢᠯᠡᠵᠦ᠂ ᠬᠤᠭᠤᠰᠤᠨ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠲᠠᠢ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤ ᠢᠯᠡᠷᠬᠡᠢ ᠵᠦᠷᠢᠶᠡ ᠲᠡᠢ᠂ P<0.05; ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ALT᠂ AST᠂ ALP᠂ TBIL ᠪᠠ ᠡᠯᠢᠭᠡᠨ ᠨᠡᠭᠡᠳᠡᠰᠦᠨ ᠦ HyP ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠳᠡᠭᠡᠭ᠍ᠰᠢᠯᠡᠵᠦ᠂ A/G ᠨᠢ ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠳᠤᠷᠤᠭᠰᠢᠯᠠᠵᠤ᠂ ᠬᠤᠭᠤᠰᠤᠨ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠲᠠᠢ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤ ᠢᠯᠡᠷᠬᠡᠢ ᠵᠦᠷᠢᠶᠡ ᠲᠡᠢ᠂ P<0.05᠃ ᠭᠠᠬᠠᠢ ᠶᠢᠨ ᠴᠢᠰᠦᠨ ᠴᠠᠢ᠌ᠪᠠᠩ ᠠᠴᠠ ᠪᠤᠯᠤᠭᠰᠠᠨ ᠲᠤᠮᠤ ᠬᠤᠯᠤᠭᠠᠨᠠ ᠶᠢᠨ ᠡᠯᠢᠭᠡᠨ ᠪᠦᠳᠦᠭᠦᠷᠡᠯ ᠡᠪᠡᠳᠴᠢᠨ ᠦ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ᠡᠯᠢᠭᠡᠨ ᠦ ᠵᠢᠭᠠᠯᠲᠠ ᠲᠤᠭᠠ ᠨᠢ ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠳᠡᠭᠡᠭ᠍ᠰᠢᠯᠡᠵᠦ᠂ ᠬᠤᠭᠤᠰᠤᠨ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠲᠠᠢ ᠬᠠᠷᠢᠴᠠᠭᠤᠯᠬᠤ ᠳᠤ ᠢᠯᠡᠷᠬᠡᠢ ᠵᠦᠷᠢᠶᠡ ᠲᠡᠢ᠂ P<0.05; ᠵᠠᠭᠪᠤᠷ ᠤᠨ ᠳᠤᠭᠤᠢ᠌ᠯᠠᠩ ᠤᠨ ALP ᠪᠠ ᠡᠯᠢᠭᠡᠨ ᠨᠡᠭᠡᠳᠡᠰᠦᠨ ᠦ HyP ᠨᠢ ᠮᠡᠳᠡᠭᠳᠡᠮᠡ ᠳᠡᠭᠡᠭ᠍ᠰᠢᠯᠡᠵᠦ᠂ A
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